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Descripción

Dual Incretin Agonist Peptide for Metabolic & Receptor-Signaling Research

Tirzepatide is a synthetic dual incretin research péptido investigated for its activity at both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptors. Its dual receptor-binding profile has made it an important compound in metabolic, endocrine, and receptor-signaling laboratory research.

SENO supplies high-purity Tirzepatide as a lyophilized sterile powder in a broad range of specifications, from TR5 (5mg × 10 vials) to TR120 (120mg × 10 vials). Each batch is manufactured using automated solid-phase peptide synthesis (SPPS), purified by RP-HPLC, and analytically verified using LC-MS.

Available specifications include:

• TR5 — 5mg × 10 vials
• TR10 — 10mg × 10 vials
• TR15 — 15mg × 10 vials
• TR20 — 20mg × 10 vials
• TR30 — 30mg × 10 vials
• TR40 — 40mg × 10 vials
• TR50 — 50mg × 10 vials
• TR60 — 60mg × 10 vials
• TR100 — 100mg × 10 vials
• TR120 — 120mg × 10 vials

This peptide is supplied exclusively for laboratory research applications.

What Is Tirzepatide?

Tirzepatide is a synthetic incretin-mimetic peptide engineered to function as a dual agonist of:

• GIP receptors
• GLP-1 receptors

The peptide was designed to investigate how simultaneous incretin receptor activation influences:

• metabolic signaling
• glucose regulation pathways
• receptor-binding dynamics
• comunicación endocrina
• energy balance mechanisms

Its structure incorporates optimized amino acid substitutions intended to enhance receptor affinity and improve resistance to enzymatic degradation during experimental use.

Compared with single-pathway incretin peptides, Tirzepatide provides researchers with a model for studying integrated hormonal signaling and dual receptor pharmacology.

The compound is supplied as a white lyophilized powder to preserve molecular stability during storage and transportation.

Aplicaciones de la investigación

Tirzepatide is widely utilized in laboratory investigations involving:

• dual incretin receptor signaling
• GLP-1 pathway research
• GIP receptor modulation studies
• metabolic regulation experiments
• glucose homeostasis research
• endocrine signaling analysis
• receptor-binding kinetics
• ligand-receptor interaction studies
• cAMP signaling investigations
• insulin pathway research models
• peptide pharmacodynamics studies
• preclinical metabolic research

The broad specification range from TR5 to TR120 supports both exploratory laboratory studies and larger-scale research workflows.

Fórmula molecular

C225H348N48O68C_{225}H_{348}N_{48}O_{68}C225​H348​N48​O68​

Peso molecular

$4813.5g/mol$

Número CAS

Especificaciones del producto

Mecanismo de acción

Tirzepatide is investigated for its dual agonist activity at both GIP and GLP-1 receptors.

GLP-1 Receptor Pathway

Research involving GLP-1 receptor activation commonly examines:

• glucose-regulatory signaling
• vías relacionadas con la insulina
• receptor internalization mechanisms
• incretin-mediated cellular responses

GIP Receptor Pathway

GIP receptor investigations may include:

• endocrine signaling dynamics
• energy metabolism pathways
• farmacología de receptores
• ligand-binding behavior

The combined receptor activity allows researchers to study how simultaneous incretin pathway modulation influences complex metabolic signaling systems.

Solubilidad

Tirzepatide is generally soluble in:

• agua estéril
• bacteriostatic water
• solución salina tamponada con fosfato (PBS)
• selected laboratory research buffers

Typical research preparation concentrations may range between:

$0.5-2mg/mL$

Actual solubility and working concentrations depend on:

• experimental design
• preparation conditions
• pH environment
• analytical requirements

Researchers often aliquot prepared solutions to reduce degradation associated with repeated freeze-thaw cycles.

Recomendaciones de almacenamiento

For optimal stability:

• Store lyophilized peptide at -20°C
• Protect from direct light and moisture
• Avoid repeated temperature fluctuations
• Maintain sterile handling procedures

Después de la reconstitución:

• Store at 2–8°C
• Use within a limited time period
• Minimize freeze-thaw exposure whenever possible

Información sobre estabilidad

Tirzepatide is supplied in lyophilized form to improve structural stability during long-term storage and transportation.

Peptide stability may be influenced by:

• temperature exposure
• oxidación
• hidrólisis
• contaminación microbiana
• pH conditions
• ciclos repetidos de congelación y descongelación

Controlled lyophilization helps reduce moisture-related degradation and supports peptide integrity during research workflows.

Estudios de investigación e interés científico

Tirzepatide has become a major focus in incretin biology and metabolic signaling research due to its dual receptor-targeting design.

Areas of scientific investigation include:

• incretin pathway interactions
• endocrine system signaling
• receptor pharmacodynamics
• glucose metabolism studies
• ligand-binding mechanisms
• cellular signaling pathways
• peptide-receptor interaction models
• integrated metabolic regulation research

Its dual agonist mechanism has expanded research interest in multi-target peptide pharmacology and combined receptor modulation strategies.

Fabricación y control de calidad

SENO manufactures Tirzepatide using automated solid-phase peptide synthesis (SPPS) systems under controlled cleanroom laboratory conditions.

El flujo de trabajo de producción incluye:

• high-purity amino acid sourcing
• optimized coupling chemistry
• automated peptide elongation
• preparative RP-HPLC purification
• LC-MS molecular verification
• liofilización estéril controlada

Each production batch undergoes analytical validation to confirm:

• integridad de la secuencia
• identidad molecular
• purity consistency
• batch reproducibility

This manufacturing process supports reliable performance in sensitive receptor-signaling and metabolic research studies.

COA (Certificado de análisis)

La documentación analítica puede incluir:

• batch number
• HPLC purity results
• LC-MS verification
• inspección de aspecto
• fecha de fabricación
• storage conditions
• quality-control confirmation

COA documentation supports laboratory traceability and internal research quality assurance.

HPLC & LC-MS Verification

Cada lote se somete a una evaluación analítica mediante:

• Reverse-Phase HPLC (RP-HPLC)
• Liquid Chromatography-Mass Spectrometry (LC-MS)

These methods help verify:

• peptide purity
• molecular weight
• sequence consistency
• evaluación de impurezas
• batch-to-batch reproducibility

Analytical chromatograms and molecular verification data may be available for laboratory documentation purposes.

Guía de reconstitución

Procedimiento de laboratorio recomendado

1. Deje que el vial se equilibre a temperatura ambiente antes de abrirlo.
2. Prepare sterile water or suitable research buffer.
3. Slowly inject solvent along the vial wall.
4. Avoid direct force onto the lyophilized powder.
5. Gently swirl until fully dissolved.
6. Do not shake vigorously.
7. Aliquot into smaller sterile containers if needed.
8. Store prepared solutions according to experimental requirements.

Researchers should optimize concentrations according to individual laboratory protocols.

Precauciones de manipulación

• Para uso exclusivo en investigación de laboratorio
• No destinado a la administración humana o veterinaria
• Use appropriate PPE during handling
• Maintain aseptic preparation conditions
• Evitar ciclos repetidos de congelación y descongelación
• Dispose of materials according to institutional safety procedures

Información de envío

• Worldwide FedEx or equivalent express shipping
• Delivered as lyophilized powder for enhanced transport stability
• Ambient temperature shipping with protective packaging
• Designed for international laboratory supply workflows

Preguntas más frecuentes (FAQ)

What is Tirzepatide used for in research?

Tirzepatide is commonly studied in metabolic, endocrine, incretin signaling, and receptor pharmacology research involving GLP-1 and GIP pathways.

Why is Tirzepatide considered a dual agonist?

The peptide is engineered to activate both GIP and GLP-1 receptors, allowing researchers to investigate integrated incretin signaling mechanisms.

Why is the peptide supplied in lyophilized form?

Lyophilization helps improve peptide stability by reducing moisture exposure during storage and international transport.

¿Qué métodos analíticos se utilizan para verificar la calidad?

Each batch is analytically verified using RP-HPLC and LC-MS to confirm purity, molecular identity, and batch consistency.

How should Tirzepatide be stored?

Lyophilized peptide should generally be stored at -20°C. Reconstituted solutions are typically stored at 2–8°C for short-term laboratory use.

Is this product intended for therapeutic or medical use?

No. Tirzepatide supplied by SENO is strictly intended for laboratory research applications only and is not approved for human or veterinary use.